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The zinc-dependent major histocompatibility complex class II binding site of streptococcal pyrogenic exotoxin C is
Timothy J Tripp1, John K McCormick, Jennifer M Webb
1Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.
Infection and Immunity
|February 22, 2003
Abstract:
The cocrystal structure of streptococcal pyrogenic exotoxin C (SPE C) with HLA-DR2a (DRA*0101,DRB5*0101) revealed a zinc-dependent interaction site through residues 167, 201, and 203 on SPE C and residue 81 on the beta-chain of HLA-DR2a (DRA*0101,DRB5*0101). Mutation of these SPE C residues resulted in dramatically reduced biological activities. Thus, the zinc-dependent major histocompatibility complex II binding site is critical for maximal biological function of SPE C.