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In vivo Imaging of Transgenic Leishmania Parasites in a Live Host
Published on: July 28, 2010
Interleukin-12 regulates chemokine gene expression during the early immune response to Leishmania major
1Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Infection and Immunity
|February 22, 2003
Abstract:
Following infection with Leishmania major, the chemokines XCL1, CXCL10, and CCL2 were preferentially expressed in draining lymph nodes of resistant mice. Neutralization of interleukin 12 (IL-12) or gamma interferon in resistant mice resulted in decreased chemokine expression, while administration of IL-12 to susceptible mice resulted in an increase in the level of chemokine gene expression.

