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Updated: Aug 12, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
[A case of coronary vasospasm treated with stent placement]
Insights
A 49-year-old woman experienced chest pain and ECG changes during hyperventilation, revealing coronary artery stenosis. Treatment resolved symptoms, highlighting hyperventilation
Area of Science:
- Cardiology
- Diagnostic Testing
- Interventional Cardiology
Background:
- Coronary artery disease can manifest with varied symptoms, including chest pain at rest.
- The interplay between fixed atherosclerotic lesions and coronary vasospasm requires further elucidation.
Observation:
- A 49-year-old woman presented with recurrent chest pain at rest.
- Hyperventilation induced significant ST-segment elevation in anterior leads (V1-V5).
- Standard bicycle stress testing did not elicit electrocardiogram (ECG) changes.
Findings:
- Coronary angiography identified significant stenosis in the left anterior descending coronary artery.
- Successful balloon angioplasty and stent implantation resolved the obstructive lesion.
- Post-intervention, hyperventilation no longer provoked chest pain or ECG abnormalities without antispastic medication.
Implications:
- Hyperventilation may serve as a valuable non-invasive provocation test for coronary vasospasm, particularly in the presence of underlying atherosclerotic disease.
- Understanding the impact of fixed lesions on vasospasm dynamics is crucial for comprehensive patient management.
- Therapeutic strategies targeting vasospasm, in conjunction with revascularization, can effectively alleviate refractory symptoms.
Abstract:
We report about a 49 year old woman with repeated chest pain at rest. During hyperventilation significant ST-segment elevation in leads V1-V5 appeared. Bicycle stress test did not provoke any ECG changes. Coronary angiography showed a significant stenosis of the left anterior descending coronary artery. Successful balloon angioplasty followed by stent implantation was performed. After an uneventful course of twelve months, hyperventilation could provoke neither chest pain nor ECG changes again without any antispastic medical treatment. Impact of fixed atherosclerotic lesions for the occurrence of coronary vasospasm, usefulness of hyperventilation as a non-invasive provocation test and therapy are discussed.
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