Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Axillary granular parakeratosis].

Gerzaín Rodríguez1

  • 1Laboratorio de Patología, Instituto Nacional de Salud, Facultad de Medicina, Universidad Nacional, Bogotá, D.C., Colombia. grodriguez@hemagogus.ins.gov.co

Biomedica : Revista Del Instituto Nacional De Salud
|February 25, 2003
PubMed
Summary

Axillary granular parakeratosis, a rare skin condition, was diagnosed in three Colombian women. Overweight individuals using antiperspirants in humid conditions may trigger this keratinization disorder.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pheohyphomycosis skin nodule in a young woman

Biomedica : revista del Instituto Nacional de Salud·2025
Same author

An 18-year-old man with tropical verrucous syndrome: Leishmaniasis or sporotrichosis?

Biomedica : revista del Instituto Nacional de Salud·2021
Same author

Leprosy in the Colombian island of Providencia

Biomedica : revista del Instituto Nacional de Salud·2020
Same author

Giant cells lepromatous leprosy. Diffuse dermatitis with exuberant foreign body giant cells in treated lepromatous leprosy

Biomedica : revista del Instituto Nacional de Salud·2019
Same author

Cutaneous leishmaniasis and pregnancy

Biomedica : revista del Instituto Nacional de Salud·2018
Same author

Cutaneous leishmaniasis and pregnancy

Biomedica : revista del Instituto Nacional de Salud·2018

Area of Science:

  • Dermatology
  • Histopathology

Background:

  • Axillary granular parakeratosis (AGP) is a keratinization disorder characterized by a thickened stratum corneum with intracellular keratohyalin granules.
  • First described in 1991, AGP has primarily been reported in the USA, Europe, and Australia, with no prior cases documented in Latin America.

Observation:

  • Three overweight Colombian women presented with encrusted, hyperkeratotic, hyperpigmented, and pruriginous papules and plaques in the axillae.
  • Lesions persisted for two months to one year, with initial clinical diagnoses including benign familial pemphigus and tinea nigra.

Findings:

  • Skin biopsies revealed a thick parakeratotic basophilic horny layer and abundant keratohyalin granules on electron microscopy.
  • Histopathology excluded Langerhans cells (S-100 IHC) and fungi (PAS stain), showing minor perivascular lymphocytic infiltration.

Related Experiment Videos

Implications:

  • The findings suggest an irritative pathogenesis for AGP, potentially triggered by factors such as obesity, antiperspirant use, local irritation, and humidity.
  • This report highlights the first cases of AGP in Latin America, expanding the known geographical distribution of this rare condition.