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Updated: Sep 27, 2026

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
Published on: March 25, 2020
[The expression of FN-IIIcs in the wound healing and its relationship with injury time]
Yan Ji1, Zi-qin Zhao, Yun-ju Gu
1Department of Forensic Medicine of Fudan University, Shanghai 200032.
Objective:
To research the expression of alternative splicing segment of fibronectin-IIIcs in incised wound of skin, to offer the experimental data for early injury time judgement.
Methods:
Using in situ hybridization with DIG-labeled anti-sense RNA probe, the expression of FN-IIIcs domain was detected in both human and rat skin incised wound.
Results:
(1) The expression of FN-IIIcs improved from the time of 30 min after injury, reached peak at 6 h and then reduced gradually. (2) The positive expression cells were mainly distributed in hair follicles, sebaceous glands and endothelium, however, in human beings they were basement cells of epidermis.
Conclusion:
The expression of FN-IIIcs domain would be a supposed useful criteria for early injury time judgement.
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