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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Anemia in chronic kidney disease and congestive heart failure

D S Silverberg1, D Wexler, B Blum

  • 1Department of Nephrology, Tel Aviv Medical Center, Israel. donald@netvision.net.il

Blood Purification
|February 25, 2003
PubMed

Insights

Anemia in chronic kidney insufficiency (CKI) and congestive heart failure (CHF) creates a dangerous cycle. Treating anemia may prevent further heart and kidney damage.

Area of Science:

  • Nephrology
  • Cardiology
  • Hematology

Background:

  • Anemia is prevalent in chronic kidney insufficiency (CKI), dialysis, congestive heart failure (CHF), and post-renal transplant.
  • Anemia can exacerbate cardiac and renal damage.
  • CHF is an underappreciated cause of anemia and a contributor to renal failure progression.

Purpose of the Study:

  • To highlight the triangular relationship between CHF, CKI, and anemia.
  • To introduce the cardio-renal anemia (CRA) syndrome.
  • To emphasize the importance of correcting anemia in CKI and CHF patients.

Main Methods:

  • The study proposes a conceptual model of the cardio-renal anemia (CRA) syndrome.
  • It reviews the interconnections between CHF, CKI, and anemia.

Main Results:

  • A vicious circle exists where CHF, CKI, and anemia exacerbate each other.
  • Anemia contributes to the progression of both cardiac and renal disease.

Conclusions:

  • Correction of anemia with erythropoietin and intravenous iron can prevent cardiac and renal deterioration.
  • Physicians, particularly cardiologists and internists, must recognize and manage anemia in CKI and CHF.
  • Collaboration between physicians and nephrologists is crucial for managing the CRA syndrome.

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