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Immunopotentiating activity of abrin, a lectin from Abrus precatorius Linn
V Ramnath1, Girija Kuttan, Ramadasan Kuttan
1Department of Physiology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur 680 651, India.
Indian Journal of Experimental Biology
|February 25, 2003
Abstract:
A non-toxic dose of abrin, (1.25 microg/kg body wt) consecutively for five days in normal mice stimulated specific humoral responses. A noticeable increase was observed in total leucocyte count, lymphocytosis, weights of spleen and thymus, circulating antibody titre, antibody forming cells, bone marrow cellularity and alpha-esterase positive bone marrow cells. The results suggest that abrin can potentiate the humoral immune response of the host.