Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does schizophrenia result from developmental or degenerative processes?

S M Church1, D Cotter, E Bramon

  • 1Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London, United Kingdom. s.church@iop.kcl.ac.uk

Journal of Neural Transmission. Supplementum
|February 25, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Climate change and health: the role of health professionals.

Irish journal of psychological medicine·2024
Same author

MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume.

International journal of clinical and health psychology : IJCHP·2024
Same author

The use of predator tags to explain reversal movement patterns in Atlantic salmon smolts (Salmo salar L.).

Journal of fish biology·2024
Same author

A short report of satisfaction levels amongst Irish trainees in psychiatry with out of hours and emergency assessments.

Irish journal of psychological medicine·2020
Same author

Psychiatric and psychosocial morbidity 1 year after epilepsy surgery.

Irish journal of psychological medicine·2020
Same author

A psychoeducational intervention increases use of a delirium protocol by Neurologists and Neurosurgeons in patients with brain disorders.

Irish journal of psychological medicine·2020

Schizophrenia research debates its origins: is it primarily a neurodevelopmental disorder or does neurodegeneration play a role after psychosis onset? This paper explores the balance between developmental deviance and potential later brain degeneration in schizophrenia.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Historical debate on schizophrenia's origin: neurodevelopmental vs. neurodegenerative.
  • Early 20th-century views favored degeneration (dementia praecox).
  • Resurgence of neurodevelopmental hypothesis in the 1980s, supported by early brain anomaly studies.

Purpose of the Study:

  • To investigate the ongoing debate regarding schizophrenia's etiology.
  • To determine if schizophrenia is solely a result of developmental deviance or involves superimposed neurodegeneration.
  • To clarify the interplay between developmental and degenerative processes in schizophrenia.

Main Methods:

  • Review of historical and contemporary research on schizophrenia's origins.
  • Analysis of neuropathological findings related to brain development and degeneration.

Related Experiment Videos

  • Examination of studies on ventricular enlargement and brain volume reduction in schizophrenia patients.

    • Main Results:

    • Neuropathological studies supporting a developmental component faced replication challenges.
    • Late 20th-century research indicated progressive brain changes (ventricular enlargement, volume reduction) post-psychosis onset.
    • Evidence suggests both developmental abnormalities and potential post-onset degeneration contribute to schizophrenia.

    Conclusions:

    • Schizophrenia likely involves a complex interplay of neurodevelopmental and neurodegenerative processes.
    • The precise contribution of each component requires further investigation.
    • Understanding these processes is crucial for developing effective treatments for schizophrenia.