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Updated: Jul 26, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
DNA-RNA-protein gang together in silence
1New York University, Plant Molecular Biology, 24-26 Waverly Place - Rm 766, New York, NY 10003, USA.
Abstract:
Two recent reports demonstrate interdependence between DNA and histone methylation in Arabidopsis. ddm1 (decrease in DNA methylation 1) mutants switch histone methylation from a form associated with inactive chromatin to a form connected to actively transcribed genomic regions. The loss of DNA methylation and shift in histone methylation cause transcriptional derepression of heterochromatic regions. In a related report, small RNAs in Schizosaccharomyces pombe mark histone methylation to form heterochromatin, suggesting that methylation systems work alongside RNA metabolism.
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