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Related Experiment Videos

Stress echo results predict mortality: a large-scale multicenter prospective international study.

Rosa Sicari1, Emilio Pasanisi, Lucia Venneri

  • 1National Council of Research, Institute of Clinical Physiology, Via G. Moruzzi 1, 56125 Pisa, Italy. rosas@ifc.cnr.it

Journal of the American College of Cardiology
|February 25, 2003
PubMed
Summary

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Pharmacologic stress echocardiography effectively predicts cardiac death in patients with coronary artery disease. A negative test indicates a favorable long-term outcome, highlighting its value in risk assessment.

Area of Science:

  • Cardiology
  • Diagnostic Imaging
  • Clinical Medicine

Background:

  • Stress echocardiography is a recognized, cost-effective method for detecting coronary artery disease (CAD).
  • Pharmacologic stress agents like dipyridamole and dobutamine are utilized when exercise stress testing is not feasible.

Purpose of the Study:

  • To evaluate the long-term predictive value of pharmacologic stress echocardiography (DET) for cardiac death in patients with suspected or confirmed CAD.
  • To assess the prognostic significance of positive versus negative DET results.

Main Methods:

  • Analysis of data from 7,333 patients (59 ± 10 years) who underwent pharmacologic stress echocardiography (dipyridamole or dobutamine).
  • Patients were followed for a mean of 2.6 years to track cardiac mortality.

Related Experiment Videos

  • Kaplan-Meier survival analysis was used to compare outcomes based on test results.

    • Main Results:

    • Pharmacologic stress echocardiography (DET) was positive for ischemia in 35% of patients and negative in 61%.
    • A total of 161 cardiac deaths occurred during follow-up (2.1%).
    • Patients with a negative DET had significantly better survival rates (92%) compared to those with a positive DET (71.2%, p=0.0000).

    Conclusions:

    • Pharmacologic stress echocardiography using dipyridamole or dobutamine is effective for predicting long-term cardiac death risk in patients with CAD.
    • A negative stress echocardiography result is strongly associated with a favorable prognosis and survival.