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Oral mixed micellar vitamin K for prevention of late vitamin K deficiency bleeding

R von Kries1, A Hachmeister, U Göbel

  • 1Institute for Social Paediatrics and Adolescent Medicine, Ludwig-Maximilians-University, Munich, Germany.

Archives of Disease in Childhood. Fetal and Neonatal Edition
|February 25, 2003
PubMed

Insights

Mixed micellar vitamin K did not significantly improve oral vitamin K prophylaxis efficacy for preventing late vitamin K deficiency bleeding in infants. The study found similar rates of bleeding regardless of vitamin K preparation used.

Area of Science:

  • Pediatric Hematology
  • Neonatal Nutrition
  • Pharmacology

Background:

  • Vitamin K deficiency bleeding (VKDB) remains a concern in infants.
  • Standard oral vitamin K prophylaxis schedules aim to prevent VKDB.
  • The efficacy of different vitamin K preparations is crucial for optimal prophylaxis.

Purpose of the Study:

  • To evaluate if mixed micellar vitamin K enhances the effectiveness of the standard 3 x 2 mg oral vitamin K prophylaxis regimen.
  • To compare the incidence of late VKDB between infants receiving mixed micellar vitamin K and those receiving other oral preparations.

Main Methods:

  • Nationwide active surveillance for VKDB cases in German infants (1997-2000).
  • Surveys assessing the use of mixed micellar vitamin K preparations in hospitals and by pediatricians.
  • Calculation of late VKDB incidence rates based on prophylaxis type.

Main Results:

  • Out of 29 confirmed VKDB cases, 17 had received the recommended oral vitamin K doses.
  • The incidence of late VKDB was 0.44/100,000 in infants given mixed micellar vitamin K versus 0.76/100,000 for other preparations.
  • No significant difference in bleeding site or cholestasis was observed between groups.

Conclusions:

  • The mixed micellar formulation of vitamin K did not demonstrate a significant improvement in preventing late VKDB compared to other oral preparations within the 3 x 2 mg schedule.
  • Current oral vitamin K prophylaxis schedules require further investigation for optimal efficacy.
Abstract

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