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New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
09:27

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Published on: May 30, 2013

Interleukin-2-associated viral breakthroughs induce HIV-1-specific CD4 T cell responses in patients on fully

Ann K Sullivan1, Gareth A Hardy, Mark R Nelson

  • 1St Stephen's Centre, Chelsea and Westminster Hospital, London, UK.

AIDS (London, England)
|February 25, 2003
PubMed

The combination of intermittent subcutaneous IL-2 and highly active antiretroviral therapy in individuals infected with HIV-1 has been shown to have a beneficial quantitative effect on the CD4 T cell count. We observed IL-2-associated viral load 'blips' inducing HIV-1-specific lymphoproliferative responses at 24 weeks in such individuals. This immunotherapeutic approach, utilizing autologous virus as autovaccination, may be a viable, safer alternative to structured treatment interruption and potentially more efficacious than therapeutic vaccines.

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