Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Malignant solid tumours in neonates: an African perspective.

G P Hadley1, D Govender, G Landers

  • 1Department of Paediatric Surgery, Nelson R. Mandela School of Medicine, University of Natal, Durban, South Africa. hadley@nu.ac.za

Pediatric Surgery International
|February 25, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transforming communication across surgical generations - bridging the gap.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2025
Same author

A quick, easy and efficient protocol for extracting high-quality RNA from Mycobacterium tuberculosis using a spin column commercial kit.

BMC research notes·2023
Same author

How does multi-set high-load resistance exercise impact neuromuscular function in normoxia and hypoxia?

European journal of sport science·2022
Same author

Immunohistochemical determination of mismatch repair gene product in colorectal carcinomas in a young indigenous African cohort.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2022
Same author

The implementation of a national paediatric oncology protocol for neuroblastoma in South Africa.

Cancer causes & control : CCC·2021
Same author

Neuroendocrine neoplasms of the digestive tract: incorporating the 2019 WHO grading schema in the South African context.

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2021

Pediatric cancers in neonates present unique challenges. This study highlights neuroblastoma and soft-tissue sarcomas as common, with varied outcomes and difficulties in risk stratification for neonatal tumors.

Area of Science:

  • Pediatric Oncology
  • Neonatal Pathology
  • Cancer Therapeutics

Background:

  • Neonatal malignant tumors exhibit distinct pathological, clinical, and therapeutic characteristics compared to older children and adults.
  • Histological appearance alone is insufficient for predicting behavior, complicating risk stratification in neonates.
  • A 20-year review of 42 patients with neonatal malignancies was conducted.

Purpose of the Study:

  • To analyze the characteristics, management, and outcomes of various malignant tumors in neonates.
  • To evaluate the effectiveness and toxicity of chemotherapy in this age group.
  • To assess risk stratification methods for neonatal neuroblastoma in the absence of specific markers.

Main Methods:

  • Retrospective review of 42 neonatal cancer patients over a 20-year period.

Related Experiment Videos

  • Initial management focused on surgical intervention where feasible.
  • Chemotherapy administration with dose reduction and monitoring for morbidity/mortality.

    • Main Results:

    • Soft-tissue sarcomas (14) were the dominant group, followed by neuroblastoma (11).
    • Congenital fibrosarcoma showed good outcomes (86% survival), while rhabdomyosarcoma had no survivors.
    • INSS staging for neuroblastoma indicated good prognosis for Stage I, uniformly fatal for Stage IV, and 50% early survival for Stage IVs.
    • Renal tumors (nephroblastoma, mesoblastic nephroma) had favorable outcomes.
    • Immature teratomas had a 29% survival rate among known survivors, with significant loss to follow-up (43%).

    Conclusions:

    • Neonatal cancers require distinct management strategies.
    • Chemotherapy in neonates carries significant risks.
    • Risk stratification for neonatal neuroblastoma relies on INSS staging.
    • Outcomes vary significantly by tumor type, with renal tumors faring well and some sarcomas having poor prognoses.