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Use of an open-reading frame-specific Campylobacter jejuni DNA microarray as a new genotyping tool for studying
Edward E Leonard1, Tohru Takata, Martin J Blaser
1Department of Microbiology and Immunology, Division of Infectious Diseases, Stanford University, Stanford, California 94305, USA. eleonard@stanford.edu
The Journal of Infectious Diseases
|February 25, 2003
Abstract:
Findings from use of an open-reading frame-specific Campylobacter jejuni DNA microarray to investigate genetic diversity among clinical isolates associated with 5 independent clusters of infection were compared with data from random amplified polymeric DNA (RAPD) and Penner serotyping analyses. The DNA microarray provides a highly specific epidemiological typing tool for analysis of C. jejuni isolates and reveals both divergent and highly conserved gene classes among isolates.