Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inflammatory mediators and reversible myocardial dysfunction.

Hong Kan1, Mitchell S Finkel

  • 1Department of Medicine (Cardiology), Robert C. Byrd Health Sciences Center, West Virginia University School of Medicine, Morgantown, West Virginia, USA.

Journal of Cellular Physiology
|February 25, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Ultrasound-assisted extraction for enhanced recovery and bioactivity of polyphenols from Tuber formosanum" [Ultrason. Sonochem. 131 (2026) 107934].

Ultrasonics sonochemistry·2026
Same author

Ultrasound-assisted extraction for enhanced recovery and bioactivity of polyphenols from Tuber formosanum.

Ultrasonics sonochemistry·2026
Same author

Cumulative excess weight exposure over time and cardiovascular risk: A prospective cohort study.

PloS one·2026
Same author

Abnormal functional connectivity networks in the nucleus accumbens correlate with migraine attack frequency and disability.

Brain imaging and behavior·2026
Same author

Comparative effectiveness of tirzepatide and semaglutide for obesity management in US clinical practice: a 6-month retrospective cohort study.

Journal of endocrinological investigation·2026
Same author

Intentional Weight Loss and Associated Cancer Incidence Among People With Overweight or Obesity: A Systematic Literature Review.

Endocrinology, diabetes & metabolism·2025

Inflammatory mediators like cytokines and nitric oxide (NO) cause heart dysfunction and beta-adrenergic desensitization. Continuous activation of protective pathways can lead to heart failure.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Pathophysiology

Background:

  • Diverse clinical conditions share common cardiac effects.
  • These include reversible myocardial dysfunction, beta-adrenergic desensitization, and inflammatory mediator activation.

Purpose of the Study:

  • To identify common mediators of myocardial dysfunction and beta-adrenergic desensitization.
  • To explore the role of inflammatory pathways in heart disease.
  • To understand the transition from protective cellular responses to heart failure.

Main Methods:

  • Review of evidence from animal models and human studies.
  • Analysis of signaling pathways involving cytokines, MAP kinases, and NO.
  • Investigation of cellular programs activated during ischemia and infection.

Related Experiment Videos

Main Results:

  • Cytokines, MAP kinases, and NO are implicated as common mediators.
  • These inflammatory mediators play a pathogenic role in both ischemic and non-ischemic myocardial dysfunction.
  • Compensatory cellular programs offer short-term protection but can lead to chronic heart failure upon continuous activation.

Conclusions:

  • Inflammatory pathways are central to various forms of heart dysfunction.
  • Understanding these pathways may allow for targeted cardioprotective therapies.
  • Preventing excessive stimulation of compensatory pathways is crucial for managing heart failure.