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Synthesis of the beta 2 agonist (R)-salmeterol using a sequence of supported reagents and scavenging agents
Robert N Bream1, Steven V Ley, Panayiotis A Procopiou
1University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Organic Letters
|February 26, 2003
Abstract:
[formula: see text] The enantioselective synthesis of (R)-salmeterol has been achieved by using a sequence of supported reagents and sequestering agents. The saligenin core was installed by a regiospecific alkylation and a chiral auxilliary approach was employed to introduce the desired stereochemistry via a diastereoselective reduction.