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A practical synthesis of meso-monosubstituted, beta-unsubstituted porphyrins
Arno Wiehe1, Claudia Ryppa, Mathias O Senge
1Institut für Chemie, Organische Chemie, Freie Universität Berlin, Takustr. 3, D-14195 Berlin, Germany.
Organic Letters
|February 26, 2003
Abstract:
[formula: see text] A simple straightforward synthesis for meso-monosubstituted, beta-unsubstituted porphyrins is reported. Porphyrins of this type are easily prepared by condensation of dipyrromethane, pyrrole-2-carbaldehyde, and the desired aromatic or aliphatic aldehyde. The method can be used for a variety of functional groups with yields between 2 and 12%. In most cases, the 5, 15-disubstituted porphyrin is obtained as a second product but can be removed easily.