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Ruthenium-catalyzed ROM-RCM of cycloalkene-yne
Miwako Mori1, Yuichi Kuzuba, Tsuyoshi Kitamura
1Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. mori@pharm.hokudai.ac.jp
Organic Letters
|February 26, 2003
Abstract:
[formula: see text] ROM-RCM (ring-opening and ring-closing metatheses) of cycloalkene-yne was demonstrated using a second-generation ruthenium complex. When cycloalkene bearing the alkyne moiety at the C-1 position was reacted with a ruthenium-carbene complex under an atmosphere of ethylene, ROM-RCM proceeded smoothly to give bicyclic compound and/or dimeric compound in good yields.