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Related Experiment Videos

Stray light-induced multifocal electroretinograms.

Yoshiaki Shimada1, Masayuki Horiguchi

  • 1Fujita Health University School of Medicine, Department of Ophthamology, Aichi, Japan. ysmd@za2.so-net.ne.jp

Investigative Ophthalmology & Visual Science
|February 26, 2003
PubMed
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Stimulating the optic disc with multifocal electroretinography (mfERG) can cause stray light, resulting in delayed responses (K1) and flat second-order kernels (K2.1). This suggests caution is needed when examining focal lesions using mfERG.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Visual Electrophysiology

Background:

  • Multifocal electroretinography (mfERG) is a key tool for assessing retinal function.
  • The optic disc, with its high reflectance, can potentially interfere with mfERG recordings.
  • Understanding stray light effects is crucial for accurate interpretation of mfERG data.

Purpose of the Study:

  • To investigate the electrophysiological responses generated when the mfERG stimulus falls directly on the optic disc.
  • To characterize the nature of stray light-induced responses in mfERG.

Main Methods:

  • mfERG and full-field pseudorandom ERGs (ffprERGs) were recorded from a patient with an enlarged optic disc and normal volunteers.
  • Stimulus intensities were varied to assess response characteristics.

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  • Analysis focused on the first-order (K1) and second-order (K2.1) kernels of the ERG responses.

    • Main Results:

    • mfERG recorded on the enlarged optic disc showed a small and delayed K1, with a flat K2.1 across all stimulus intensities.
    • The implicit time of K1 varied with stimulus intensity, being longer at lower intensities.
    • ffprERGs at very low intensities in both the patient and controls mimicked the mfERG response on the disc (delayed K1, flat K2.1).

    Conclusions:

    • Optic disc stimulation in mfERG can lead to delayed K1 and flat K2.1 responses.
    • High optic disc reflectance likely scatters stimulus light, creating a weak, full-field stimulus effect.
    • Clinicians should exercise caution when using mfERG to evaluate focal lesions near or on the optic disc to avoid misinterpretation due to stray light.