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Hippocampal sclerosis is a progressive disorder: a longitudinal volumetric MRI study
Darren Fuerst1, Jagdish Shah, Aashit Shah
1Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Annals of Neurology
|February 26, 2003
Abstract:
Twelve patients with refractory temporal lobe epilepsy and unilateral hippocampal sclerosis had repeat volumetric magnetic resonance imaging scans after a mean of 3.4 years to determine whether progressive hippocampal volume loss occurred. Seizure-free patients showed no change in hippocampal volume. Patients with continuing seizures had a decline in ipsilateral hippocampal volume that correlated with seizure frequency. Patients with medically refractory temporal lobe epilepsy and unilateral hippocampal sclerosis have progressive hippocampal atrophy.