[Therapy of diffuse suppurative peritonitis with continuous peritoneal lavage]

Area of Science:

• Abdominal Medicine
• Critical Care Medicine
• Surgical Gastroenterology

Background:

• Peritonitis presents a significant clinical challenge with high mortality rates.
• Diverse treatment strategies exist for managing peritonitis.
• Continuous peritoneal lavage (CPL) is one such therapeutic modality.

Purpose of the Study:

• To retrospectively analyze the efficacy and outcomes of continuous peritoneal lavage (CPL) in patients with peritonitis.
• To identify factors influencing the prognosis of peritonitis patients treated with CPL.

Main Methods:

• Retrospective analysis of 510 patients with peritonitis treated with CPL over 12 years.
• Data collected included patient demographics, comorbidities, severity scores (APACHE-II), peritonitis type, treatment duration, and outcomes.
• Statistical analysis focused on successful treatment rates, reoperation rates, and mortality.

Main Results:

• 81.3% of patients treated with CPL achieved successful outcomes.
• The overall mortality rate was 18.7%.
• Patients requiring reoperation had a significantly higher mortality rate (37.0%) compared to primarily treated patients (15.6%).
• Preexisting organ failure and duration of peritonitis on admission were significant prognostic factors.

Conclusions:

• Continuous peritoneal lavage (CPL) demonstrates considerable success in managing peritonitis, particularly diffuse forms.
• Early diagnosis and treatment initiation are crucial for improving patient prognosis.
• Management of comorbidities and organ failure is essential for optimizing CPL outcomes in peritonitis patients.