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[The influence of transdermal nitroglycerin patches on fetal blood flow parameters in threatened preterm labor]
Bozena Leszczyńska-Gorzelak1, Beata Marciniak, Marzena Laskowska
1Kliniki Połoznictwa i Perinatologii AM w Lublinie, kierownik Kliniki.
Objectives:
The aim of our study was the assessment of fetal arterial Doppler parameters (umbilical artery and middle cerebral artery) in threatened preterm labor in the course of transdermal nitroglycerin therapy.
Materials And Methods:
16 pregnant women in between 27th and 34th week of gestation with symptoms of threatening preterm labor were brought into our study. Patients were treated with transdermal nitroglycerin (5 mg) patches. Maternal blood pressure. Manning's test score and fetal arterial Doppler blood flow were measured.
Results:
Whereas maternal systolic blood pressure does not vary in the course of therapy, significant decrease in diastolic blood pressure was noted. There was no change in the mean umbilical and middle cerebral artery blood flow in the course of treatment.
Conclusions:
Nitroglycerin in the form of transdermal therapeutic system releasing nitric oxide doesn't effect fetal artery Doppler parameters. Nitroglycerin may be used as a safe therapeutic agent in treatment of preterm labor.