Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Antibody response in common variable immunodeficiency.

Waleed Al-Herz¹, Stephen J McGeady

¹Division of Allergy & Clinical Immunology, Nemours Children's Clinic-Wilmington, Alfred I. duPont Hospital for Children, Wilmington, Delaware 19899, USA.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology

|February 27, 2003

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

MTHFD1 Deficiency in Two Unrelated Children: Highlights on Phenotypic Spectrum and Response to Folic Acid Therapy.

Journal of pediatric hematology/oncology·2026

Same author

Editorial Expression of Concern: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.

Nature immunology·2026

Same author

Increased IGF-1 and DNA Synthesis in Patients With Activation-Induced Cytidine Deaminase Deficiency.

Journal of immunology research·2026

Same author

Recessive loss of DIAPH1 function causes a progressive neurodevelopmental syndrome with variable immunological involvement.

Genetics in medicine : official journal of the American College of Medical Genetics·2026

Same author

An SP110-SP100 axis is a critical regulator of promyelocytic leukaemia body dynamics and mitotic fidelity.

Nature cell biology·2026

Same author

The MENAT Region Inborn Errors of Immunity Research Consortium Registry (MENAT-IEI-RCR): Establishing a regional framework for collaborative research.

Clinical immunology (Orlando, Fla.)·2026

Same journal

Overlapping Mechanisms and Novel Biomarkers Define Asthma and COPD as a Spectrum of Airway Disease.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026

Same journal

Real-World Variation in Post-Dose Supervision and Activity Restriction During Maintenance Cow's Milk Oral Immunotherapy.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026

Same journal

Small Airway Dysfunction and Prior Exacerbations are Common in Primarily Well-Controlled Pediatric Asthma.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026

Same journal

Elevated Absolute Eosinophil Counts are Associated with Hypertension, Coronary Heart Disease, and Stroke.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026

Same journal

Pharmacokinetics and pharmacodynamics of AQST-109 sublingual film in oral allergy syndrome: A phase 2 study.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026

Same journal

Biomarkers for COPD with Type 2 Inflammation.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026

See all related articles

Patients with common variable immunodeficiency (CVID) often lose antibody response to polysaccharides first. Protein antibody response may remain, even with low immunoglobulin levels.

Area of Science:

Immunology
Clinical Medicine

Background:

Common variable immunodeficiency (CVID) is a diverse group of immune disorders with unknown causes.
Characterized by low serum immunoglobulin (Ig) levels and poor antibody production.

Observation:

Study reviewed clinical and immunologic data of four CVID patients.
Focused on antibody response patterns and immunoglobulin G (IgG) decline kinetics.

Findings:

Antibody response to polysaccharide antigens is diminished earlier in CVID patients compared to protein antigens.
Protein antigen antibody response can be preserved despite severe hypogammaglobulinemia.
IgG levels showed a progressive decline in three prospectively monitored patients.

Implications:

Related Experiment Videos

Loss of polysaccharide antibody response may be a hallmark of CVID.
Preserved T cell-dependent protein antibody response is possible in CVID.
Understanding these patterns aids in CVID diagnosis and management.