Related Experiment Videos
The controlled release study of Vincristine Sulfate
Yong Sun1, Lisa Xu, Qiqing Zhang
1National Pharmaceutical Research Center, Lunan Pharmaceutical Corporation, Linyi City, Shandong, China.
Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
|February 27, 2003
Abstract:
We prepared microspheres of Vincristine Sulfate (VCR) through drying-from-oil method, then mixed the microspheres into 0.7% collagen swelling solution to prepare emulsion, spread the emulsion on plate to form film by frozen-dry method. The film was cross-linked and sterilized, then planted into the site of tumor and expected to release at steady speed. We measured the release of VCR in vivo and in vitro by HPLC. The results demonstrated that VCR controlled release films release at approximate steady speed in 15 days.