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Related Experiment Videos

Complement and meningococcal infection.

B M Greenwood, I I Onyewotu, H C Whittle

    British Medical Journal
    |April 3, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Low serum C3 levels in meningococcal disease patients indicate complement activation, potentially causing circulatory collapse and death. Transient C3 drops also suggest immune complex formation linked to allergic complications.

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    Area of Science:

    • Immunology
    • Infectious Diseases
    • Complement System

    Background:

    • Meningococcal disease is a serious infection.
    • The role of the complement system in meningococcal disease pathogenesis is not fully understood.

    Purpose of the Study:

    • To investigate serum C3 levels in patients with meningococcal disease.
    • To explore the association between C3 levels and disease severity, complications, and outcomes.

    Main Methods:

    • Serum C3 levels were measured in 211 patients with meningococcal disease.
    • Complement pathways (classical and alternative) were assessed.
    • Serial C3 measurements were performed in a subset of patients.

    Main Results:

    • Low C3 levels were observed in 13 patients with acute meningococcaemia, correlating with circulatory collapse and mortality.

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  • Complement activation, involving both classical and alternative pathways, was indicated.
  • Patients with meningitis had higher mean C3 levels than controls.
  • A transient fall in C3 was noted in 8/13 patients who developed arthritis or cutaneous vasculitis, suggesting immune complex formation.

    • Conclusions:

    • Complement activation, particularly involving C3, plays a significant role in the pathogenesis of severe meningococcal disease.
    • Low C3 levels are associated with poor outcomes, including circulatory collapse and death.
    • Transient C3 depletion may indicate immune complex-mediated complications like arthritis and vasculitis.