Breast cancer in reduction mammaplasty specimens: case reports and guidelines
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Updated: Sep 27, 2026

Processing of Human Reduction Mammoplasty and Mastectomy Tissues for Cell Culture
Published on: January 3, 2013
Angela J Keleher1, Howard N Langstein, Frederick C Ames
1Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
Abstract:
Increasing numbers of women of all ages are electing to have reduction mammaplasty for very large breasts. Breast cancer can be an incidental finding in reduction mammaplasty specimens. We report here the discovery of breast cancer in specimens from four patients who underwent elective breast reduction, three of whom had not had recent mammograms. All four patients underwent modified radical mastectomy. The role of mammography, surgical options, specimen evaluation, and practical guidelines are discussed.
