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Hyperhomocysteinaemia is associated with coronary events in type 2 diabetes

A Becker1, P J Kostense, G Bos

  • 1Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, the Netherlands.

Journal of Internal Medicine
|February 27, 2003
PubMed

Insights

High homocysteine levels significantly increase coronary event risk in type 2 diabetes patients, independent of other factors. This association was not observed in individuals without diabetes, suggesting a specific interaction.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Metabolic Syndrome

Background:

  • High serum homocysteine is a known risk factor for coronary events in non-diabetic individuals.
  • The impact of homocysteine on coronary event risk in type 2 diabetes remains unclear.

Purpose of the Study:

  • To investigate the combined effect of homocysteine and type 2 diabetes on the risk of fatal and nonfatal coronary events.

Main Methods:

  • A 10-year risk assessment of coronary events was conducted in diabetic (n=140) and non-diabetic (n=361) individuals aged 50-75 years.
  • The study utilized data from the population-based Hoorn Study.

Main Results:

  • Diabetic individuals had a higher incidence rate of coronary events (2.63 per 100 person-years) compared to non-diabetic individuals (1.29 per 100 person-years).
  • In diabetic individuals, each 5-micromol/L increment in homocysteine increased coronary event risk by 28% (HR 1.28), independent of traditional risk factors.
  • Homocysteine was not associated with increased coronary event risk in non-diabetic participants (HR 0.86).

Conclusions:

  • Homocysteine is significantly associated with coronary events in individuals with type 2 diabetes, irrespective of traditional cardiovascular risk factors.
  • Further research into vitamin B treatment for individuals with type 2 diabetes is recommended to assess its impact on prognosis.
Abstract

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