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Updated: Aug 13, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
Bone marrow transplantation: it's not just about blood anymore!
1Division of Stem Cell Transplantation and Experimental Hematology, St Jude Children's Research Hospital, 332 N. Lauderdale Street, Memphis, TN 38105, USA. Edwin.horwitz@stjude.org
Abstract:
Bone marrow transplantation is established as effective cell therapy for hematopoietic disorders. With the recognition that bone marrow also contains mesenchymal stem cells, with the potential to differentiate to a wide variety of mesenchymal tissues, bone marrow transplantation, in theory, may be used to treat many nonhematopoietic disorders as well. Here, we present an overview of the developments of clinically oriented marrow mesenchymal stem cell biology and it's early applications as adjunct cell therapy in conventional stem cell transplantation, and most importantly as stem cell therapy for nonhematopoietic disorders.
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