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Updated: Aug 9, 2026

Depletion and Reconstitution of Macrophages in Mice
Published on: August 1, 2012
Clodronate liposomes: perspectives in research and therapeutics
Nico van Rooijen1, Esther van Kesteren-Hendrikx
1Department of Molecular Cell Biology, Research Institute of Immunology & Inflammation, Faculty of Medicine, Vrije Universiteit Van der Boechorststraat, Amsterdam, The Netherlands.
Abstract:
Liposomes encapsulating the bisphosphonate clodronate can be used for the transient suppression of macrophage functions. Given the important role of macrophages in various disorders, the application of clodronate liposomes has been studied in several models of rheumatoid arthritis, neurological disorders such as experimental allergic encephalomyelitis and spinal cord injury, autoantibody mediated disorders such as immune thrombocytopenic purpura (ITP) and for the improvement of the efficacy of gene transfer and drug targeting.
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