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Related Experiment Videos

Follicular liposomal delivery systems.

Susan Niemiec Ciotti1, Norman Weiner

  • 1Johnson & Johnson Consumer Products, Skillman, NJ 08558, USA.

Journal of Liposome Research
|February 27, 2003
PubMed
Summary

Novel liposomes enhance topical delivery of minoxidil and plasmid DNA to hair follicles for treating skin conditions like hair loss. This research explores appenageal transport for localized drug action.

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Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro.

Journal of pharmaceutical sciences·2009
See all related articles

Area of Science:

  • Dermatology and Pharmaceutical Sciences
  • Nanotechnology in Drug Delivery
  • Molecular Biology

Background:

  • Traditional topical drug delivery relies on stratum corneum penetration.
  • Appenageal transport, specifically via hair follicles, is an emerging route for topical delivery.
  • Targeting hair follicles offers a promising strategy for treating skin and hair loss conditions.

Purpose of the Study:

  • To develop novel liposomal formulations for enhanced topical delivery.
  • To facilitate the localized delivery of difficult-to-absorb agents to hair follicles and sebaceous glands.
  • To investigate the delivery of both small molecules (minoxidil) and large molecules (plasmid DNA) via liposomes.

Main Methods:

  • Formulation of novel liposomes for topical application.
  • Evaluation of liposomal delivery of minoxidil (small molecule) for hair growth.
  • Assessment of liposomal delivery of plasmid DNA encoding interleukin-1 receptor antagonist protein (IL-1ra) (large molecule).

Main Results:

  • Demonstrated successful formulation of liposomes capable of carrying diverse molecular weights.
  • Showcased potential for liposomal carriers to target hair follicles and sebaceous glands.
  • Provided evidence for appenageal transport as a viable route for topical drug delivery.

Conclusions:

  • Novel liposomal formulations can effectively deliver both small and large molecules topically.
  • Targeted delivery to hair follicles via liposomes represents a viable strategy for treating localized skin conditions.
  • This approach broadens the scope of topical drug delivery for challenging therapeutic agents.

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