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Related Experiment Videos

Human immunodeficiency virus (HIV)-associated polymorphic lymphoproliferative disorders.

Roland G Nador1, Amy Chadburn, Girija Gundappa

  • 1Department of Pathology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.

The American Journal of Surgical Pathology
|February 27, 2003
PubMed
Summary

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Polymorphic B-cell lymphoproliferative disorders, similar to those in transplant recipients, are found in HIV-infected individuals. Further research is needed to determine their malignant status and significance.

Area of Science:

  • Hematology
  • Oncology
  • Virology

Background:

  • AIDS-related lymphomas are typically aggressive B-cell types.
  • Posttransplantation lymphoproliferative disorders (PT-LPDs) are heterogeneous, Epstein-Barr virus (EBV)-driven B-cell proliferations.
  • Atypical lymphoid proliferations in HIV infection warrant further investigation.

Purpose of the Study:

  • To identify and characterize HIV-associated lymphoid proliferations resembling polymorphic PT-LPDs.
  • To investigate the clonal composition and molecular features of these lesions.
  • To explore the potential role of EBV and Kaposi's sarcoma-associated herpesvirus.

Main Methods:

  • Retrospective histopathologic review of 10 HIV-associated lymphoid proliferations.
  • Southern blotting for immunoglobulin and EBV gene rearrangement.

Related Experiment Videos

  • Analysis of C-MYC, BCL-6, RAS, and p53 gene mutations.
  • Polymerase chain reaction and in situ hybridization for Kaposi's sarcoma-associated herpesvirus detection.

    • Main Results:

    • Eight of 10 cases (80%) showed evidence of a clonal B-cell population, often a subpopulation.
    • One case transformed to diffuse large cell lymphoma with C-MYC, BCL-6, and p53 mutations.
    • Clonal EBV infection (type A) was detected in 40% of lesions.
    • Kaposi's sarcoma-associated herpesvirus was detected in two cases.

    Conclusions:

    • HIV-infected individuals can develop polymorphic B-cell lymphoproliferative disorders similar to PT-LPDs.
    • These disorders exhibit variable clonal composition and molecular alterations.
    • Their malignant potential, biologic significance, and relationship to other lymphomas require further study.