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Renal-type clear cell carcinoma occurring in the prostate
Herb Singh1, Nery Flores-Sandoval, Jacki Abrams
1Department of Urology, St. Luke's Episcopal Hospital, Houston, Texas, USA.
The American Journal of Surgical Pathology
|February 27, 2003
Summary
A rare clear cell carcinoma, typically found in the kidney, was unexpectedly identified in the prostate of a 73-year-old man. This case highlights a potential new extrarenal tumor presentation requiring careful diagnosis.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Clear cell lesions in the urinary tract pose diagnostic difficulties.
- The differential diagnosis for prostatic lesions includes various epithelial and stromal tumors.
Observation:
- A 73-year-old male presented with hematuria.
- Transurethral resection of the prostate revealed a lesion morphologically and immunohistochemically similar to renal clear cell carcinoma.
- Extensive workup, including imaging and biopsies, failed to identify a primary renal tumor or clear cell component in subsequent prostatic tissue.
Findings:
- The prostatectomy specimen revealed organ-confined prostatic adenocarcinoma (Gleason's 3 + 3).
- No residual clear cell carcinoma was identified in the final pathology.
- The urinary bladder and lymph nodes were negative for malignancy or dysplasia.
Implications:
- This case suggests a possible primary renal-type clear cell carcinoma arising in the prostate, an unprecedented extrarenal presentation.
- The findings underscore the importance of comprehensive histopathological evaluation and immunohistochemistry in diagnosing challenging urinary tract lesions.
- Further research is warranted to understand the etiology and behavior of such rare prostatic clear cell lesions.