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Determinants of left atrial size in patients with newly diagnosed untreated hypertension

George A Mansoor1, Ranjit Suri, William B White

  • 1University of Connecticut Health Center, Farmington, Connecticut 06030, USA. mansoor@nso1.uchc.edu

Blood Pressure Monitoring
|February 27, 2003
PubMed

Insights

Body mass index and left ventricular mass are key factors influencing left atrial size in individuals with untreated hypertension. These factors, along with blood pressure, are crucial for understanding cardiac remodeling in early hypertension.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Echocardiography

Background:

  • Hypertension is a major risk factor for cardiovascular disease, often leading to cardiac structural changes.
  • Left atrial size is an important indicator of cardiovascular health and a predictor of adverse events.
  • Understanding the early determinants of left atrial remodeling in untreated hypertension is crucial for timely intervention.

Purpose of the Study:

  • To investigate the relationship between ambulatory blood pressure, left ventricular mass, body mass index, and other clinical variables with left atrial size.
  • To identify the primary predictors of left atrial size in newly diagnosed, never-treated hypertensive patients and normotensive controls.

Main Methods:

  • Uni-dimensional M-mode echocardiography was used to measure left atrial size.
  • Ambulatory blood pressure monitoring and office blood pressure measurements were performed.
  • Left ventricular mass and wall thickness were assessed in 58 hypertensive and 28 normotensive subjects.

Main Results:

  • Hypertensive subjects exhibited significantly increased left ventricular mass and wall thickness compared to normotensive controls.
  • Left atrial size and left ventricular internal diameter did not differ significantly between the groups.
  • Body mass index, left ventricular mass, and 24-h pulse pressure were significant correlates of left atrial size in the overall cohort.

Conclusions:

  • Body mass index and left ventricular mass are the principal correlates of left atrial size in patients with untreated stage I-II hypertension.
  • These findings highlight the importance of managing body mass and cardiac remodeling in early hypertensive disease.

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