Relation of coronary artery calcium to left ventricular mass and geometry in patients with essential hypertension

There is a close relationship between left ventricular hypertrophy and cardiovascular diseases that are observed in hypertension. In this study, the amount of coronary artery calcium, which is an indicator of atherosclerosis, has been measured and its relationship with left ventricular hypertrophy and geometry and other traditional risk factors has been investigated.

A total of 249 (104 females, 145 males) hypertensive asymptomatic patients, without diabetes with an average age of 55.09 +/- 11.32 years were included in the study. Left ventricular mass of the patients was measured with M-mode echocardiography and coronary artery calcium with electron beam tomography. The average age of the patients who had calcium in their coronary arteries (CAC+) was 59.99 +/- 9.85 years, and the average age of the ones without calcium (CAC-) was 49.29 +/- 10.19 years.

Mean left ventricular mass index (LVMI) was measured as 130.18 +/- 43.24 g/m2 in CAC+ patients and as 108.47 +/- 29.09 g/m2 in CAC- patients. These two groups did not differ in terms of the parameters such as total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride and uric acid levels, the presence of early coronary disease in the family and smoking. Patients who had calcium in their coronary arteries (CAC+) were more obese (P < 0.004). In the logistic regression analysis, we demonstrated that body mass index and age were the factors affecting the presence and amount of calcification seen in coronary arteries in left ventricular hypertrophy. In the analysis performed by taking left ventricular hypertrophy into consideration, mean calcium scores of the patients with normal remodeling, concentric remodeling, eccentric hypertrophy and concentric hypertrophy were 50.9 +/- 187.4, 68.6 +/- 159.3, 92.2 +/- 160.2 and 315.4 +/- 760.6, respectively. In the patients with concentric left ventricular hypertrophy (LVH), the mean calcium scores of the coronary arteries and the rate of being CAC+ were significantly high, although these patients were also older. After linear regression, the relationship between concentric LVH and coronary artery calcium (CAC) was still significant.

In conclusion, left ventricular hypertrophy that is observed in hypertension is an important risk factor for sub-clinical atherosclerosis. Concentric left ventricular hypertrophy is a more important risk factor than other geometric patterns.