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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

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Silent myocardial ischaemia in treated hypertensives with and without left ventricular hypertrophy

Milos M Stojanovic1, Eoin O'Brien, Simon Lyons

  • 1Blood Pressure Unit and ADAPT Centre, Beaumont Hospital, Dublin 9, Ireland.

Blood Pressure Monitoring
|February 27, 2003
PubMed

Insights

Hypertensive patients with left ventricular hypertrophy (LVH) show a significantly higher prevalence of silent ischaemia compared to those without LVH. Ambulatory ECG monitoring can help identify high-risk patients for cardiovascular complications.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Ischaemia Studies

Background:

  • Silent ischaemia increases risk for myocardial infarction and sudden death.
  • Left ventricular hypertrophy (LVH) is common in hypertensive patients.
  • Prevalence of silent ischaemia in hypertensive patients with and without LVH requires examination.

Purpose of the Study:

  • To investigate the prevalence of silent ischaemia in hypertensive patients.
  • To compare silent ischaemia in hypertensive patients with and without LVH.

Main Methods:

  • 24-h ambulatory blood pressure and ECG monitoring used.
  • Included 20 hypertensive patients with LVH and 20 matched controls without LVH.
  • Ischaemic events defined by asymptomatic ST-depression criteria.

Main Results:

  • 13/20 patients with LVH experienced ischaemic events vs. 4/20 without LVH.
  • Median ischaemic events were significantly higher in the LVH group (7 vs. 0).
  • Median total ischaemic area was significantly greater in hypertensive patients with LVH.

Conclusions:

  • Silent ischaemia prevalence is markedly increased in hypertensive patients with LVH.
  • Ambulatory ECG monitoring aids in identifying high-risk hypertensive patients.
  • LVH indicates increased risk for cardiovascular complications and sudden death.
Abstract

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