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Related Experiment Videos

A low-grade extraskeletal osteosarcoma.

Kyoji Okada1, Hiroki Ito, Naohisa Miyakoshi

  • 1Department of Orthopedic Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan. cshokada@med.akita-u.ac.jp

Skeletal Radiology
|February 28, 2003
PubMed
Summary

A rare low-grade extraskeletal osteosarcoma in a 35-year-old woman was successfully treated with wide excision. This case highlights the importance of accurate diagnosis for effective management of extraskeletal bone tumors.

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Area of Science:

  • Orthopedic Oncology
  • Surgical Pathology
  • Radiology

Background:

  • Extraskeletal osteosarcoma is a rare malignant bone tumor occurring outside the skeleton.
  • Low-grade variants present diagnostic challenges, often mimicking benign conditions like myositis ossificans.
  • Accurate histological and radiological assessment is crucial for correct diagnosis and treatment planning.

Observation:

  • A 35-year-old woman presented with a low-grade extraskeletal osteosarcoma of the left leg.
  • Radiographs revealed peripheral ossification, initially suggesting myositis ossificans.
  • Histological examination showed a predominantly cartilaginous tumor with mild-to-moderate chondrocyte atypia and peripheral bone formation.

Findings:

  • The tumor exhibited features consistent with low-grade extraskeletal osteosarcoma, including mild cellular atypia and spindle cell proliferation.

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  • Immunohistochemical analysis showed an average MIB-1 proliferation index of 9.0%.
  • The diagnosis was confirmed based on combined histological and MIB-1 index findings.

    • Implications:

    • Wide excision is an effective treatment for low-grade extraskeletal osteosarcoma, leading to favorable outcomes.
    • This case underscores the importance of differentiating extraskeletal osteosarcoma from benign mimics through comprehensive evaluation.
    • Long-term follow-up confirmed an uneventful clinical course 47 months post-surgery.