Related Experiment Video
Updated: Aug 9, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
Published on: December 1, 2016
Cancer "photo-chemoprevention" with pulsed dye laser and celecoxib
Zhi Wang1, Cesar F Fuentes, Stanley M Shapshay
1Department of Otolaryngology Head and Neck Surgery, Boston Medical Center/Boston University School of Medicine, Massachusetts 02118, USA. zwang@bu.edu
Background And Objectives:
Our previous study demonstrated the efficacy of pulsed dye laser (PDL) in inhibiting cancer growth. This study is to determine the synergic effect of PDL and Celecoxib, when they are combined for treatment of oral cancer.
Study Design/Materials And Methods:
Fifteen mice were inoculated with oral cell carcinoma and divided into three groups of five each (30 seeding sites/group): (1) control (no treatment), (2) PDL only, and (3) treatment with combined PDL and Celecoxib (1,500 ppm). The number and volume of tumors were counted and measured for 21 days.
Results:
The combined treatment developed tumor at the slowest rate. On day 21, the average tumor volumes were (1) 483.6 mm(3) (control), (2) 312.1 mm(3) (PDL only), and (3) 151.4 mm(3) (combined treatment).
Conclusions:
A synergic effect was found in the combined treatment group. This study provides the first evidence of the efficacy of a new strategy for the treatment of oral cancer, namely, cancer "photo-chemoprevention."
Related Concept Videos
Cancer Prevention
Some...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Cancer Prevention
Some...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...

