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Regioselective reductive coupling of alkynes and aldehydes leading to allylic alcohols
Kazuhiko Takai1, Shuji Sakamoto, Takahiko Isshiki
1Department of Applied Chemistry, Faculty of Engineering, Okayama University, Tsushima, Okayama 700-8530, Japan. ktakai@cc.okayama-u.ac.jp
Organic Letters
|February 28, 2003
Abstract:
Treatment of a mixture of a terminal alkyne and an aldehyde with CrCl(2) and a catalytic amount of NiCl(2) and triphenylphosphine in the presence of water in DMF at 25 degrees C gives a 1,2-disubstituted allylic alcohol regioselectively.