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Updated: Sep 27, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Translocation (X;20)(q13.1;q13.3) as a primary chromosomal finding in two patients with myelocytic disorders
Brian A Gray1, Dennis Cornfield, Angela Bent-Williams
1Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL, USA.
Abstract:
Reports of X chromosome translocations, as primary chromosomal changes associated with hematologic disorders, remain relatively uncommon. Herein, we report the detection, by conventional cytogenetic methods, of a cytogenetically identical t(X;20) in two different patients with hematologic disorders (probable myelodysplasia and polycythemia vera/acute myelocytic leukemia). In both cases, this translocation appeared as the primary clonal chromosome abnormality, with breakpoints occurring in the long arms of both the X chromosome and chromosome 20 (Xq13.1 and 20q13.3, respectively). Further characterization and comparison of the translocation chromosome products of these two cases by use of fluorescence in situ hybridization techniques is also described. Similar previously reported cytogenetically cases and the potential that this specific rearrangement may represent a nonrandom chromosomal finding are discussed.
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