Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oligodendroglia in developmental neurotoxicity.

Wenbin Deng1, Ronald D Poretz

  • 1Department of Biochemistry and Microbiology, Rutgers University, 76 Lipman Drive, New Brunswick, NJ 08901-8525, USA.

Neurotoxicology
|February 28, 2003
PubMed
Summary

Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), are increasingly recognized as critical targets in developmental neurotoxicity. This article highlights their unique biology and role in toxicological studies, using lead exposure as an example.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metal ion-based therapeutic strategies for diabetic wound healing: Mechanisms, biomaterial platforms, and translational challenges.

Biomaterials·2026
Same author

Author Correction: mRNA vaccine developed for sequential selective organ-to-cell targeting of glioma.

Nature communications·2026
Same author

Endocytosis-dependent and spleen-selective mRNA expression enabled by ionizable lipidoid linkers enhances therapeutic mRNA vaccination.

Acta biomaterialia·2026
Same author

Nitazoxanide cooperates with cytarabine to inhibit cytarabine-resistant acute myeloid leukemia progression via mitochondrial dysfunction and PLK1 suppression.

Biochemical pharmacology·2026
Same author

Influence mechanisms of rock mass discontinuity density on mining-induced land subsidence.

Scientific reports·2026
Same author

A single nucleotide polymorphism that affects oligodendroglial lineage cells may augment the consequences of neurotoxicants.

Neurotoxicology·2026

Area of Science:

  • Neuroscience
  • Toxicology
  • Developmental Biology

Background:

  • The developing nervous system is vulnerable to toxicants, with research historically focusing on neurons and astroglia.
  • The role of oligodendroglia, myelin-forming cells in the central nervous system (CNS), in developmental neurotoxicity is a recent area of emphasis.
  • Oligodendrocyte lineage cells possess functions beyond myelination, including roles in neuronal survival, development, neurotransmission, and synaptic function.

Purpose of the Study:

  • To examine recent advancements in oligodendroglial biology.
  • To highlight the oligodendrocyte developmental lineage as a model for neurotoxicological studies.
  • To explore the involvement of oligodendrocyte lineage cells in developmental neurotoxicity.

Main Methods:

Related Experiment Videos

  • Review of current literature on oligodendroglial biology and developmental neurotoxicity.
  • Analysis of the oligodendrocyte developmental lineage characteristics for toxicological assessment.
  • Case study examining the role of oligodendroglia in environmental lead neurotoxicity.

    • Main Results:

    • Oligodendrocyte lineage cells undergo distinct phenotypic stages during differentiation, with varying proliferative and migratory capacities.
    • Knowledge of oligodendroglial survival, migration, proliferation, and differentiation control is substantial.
    • Emerging research indicates oligodendrocyte lineage cells are involved in neurotoxic processes.

    Conclusions:

    • The oligodendrocyte developmental lineage offers a valuable model system for studying developmental neurotoxicity.
    • Understanding oligodendroglial responses to toxicants is crucial for assessing neurodevelopmental risks.
    • Environmental toxicants like lead may significantly impact CNS development by targeting oligodendroglia.