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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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[Factor VII, a therapeutic alternative in the treatment of severe haemoghage disorders]

V Morales León1, G Herrera Ortega, R Molero Gómez

  • 1Servicio de Farmacia, Hospital de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35020 Spain. victormorales@redfarma.es

Farmacia Hospitalaria : Organo Oficial De Expresion Cientifica De La Sociedad Espanola De Farmacia Hospitalaria
|February 28, 2003
PubMed

Plasmatic coagulation has like purpose the formation of a stable clot of fibrina, this process is possible thanks to the intervention of the factors of the coagulation that are plasmatic proteins. Some of these factors are vitamin K dependent (factors II, VII, IX and X) and all except for the factors VIII, XII and XIII which are synthesized in the liver. Three clinical cases of patients are described who present serious hemorrhagic disorders, associated to different hepatic alterations, which do not respond to conventional treatments. As a measure of urgency and therapeutic alternative, the administration of recombinant factor VII is used with the aim of activating the extrinsic pathway of the coagulation and of obtaining a positive answer in the control of the hemorrhage.

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