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Updated: Aug 15, 2026

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation
10:58

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation

Published on: August 21, 2019

[Conjugated polymer-subunit immunogens and vaccines]

R V Petrov, R M Khaitov

    Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
    |March 1, 2003
    PubMed

    A study of fundamental mechanisms regulating the immune response resulted in producing a theory explaining the mechanism of immunostimulating properties of polyelectrolytes, as well as in working out the principles for creating the synthetic immunomodulators and, on the basis of them, polymer-subunit immunogens and vaccines. The above theory produced a basis for creating polyoxidonium, a new polymer polyelectrolyte, which was used to synthesize the conjugated polymer-subunit "Grippol" vaccine that, after its commissioning into production, has been widely used.

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