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[Adverse effects following vaccinations and effectiveness of different live vaccines against mumps]
Abstract:
The paper analyses adverse effects with special emphasis on meningitis following mumps vaccination with vaccines containing different strains of mumps virus. It also provides information on the comparative effectiveness of different types of vaccines. Information is based on the review of literature and data collected in the Department of Epidemiology, National Institute of Hygiene in Warsaw. Most of the data provides evidence that risk of aseptic meningitis following vaccines containing Jeryl Lynn strains of the mumps virus is generally smaller than the risk following vaccines based on Urabe AM 9 strain. Studies on vaccine effectiveness showed moderately higher effectiveness of vaccines based on Urabe AM 9. The main aim of this paper was to provide comprehensive information on the effectiveness and safety of mumps vaccines registered in Poland for the purpose of decisions making on their use.
Insights
Mumps vaccines containing Jeryl Lynn strains show a lower risk of aseptic meningitis compared to Urabe AM 9 strains. However, Urabe AM 9 vaccines demonstrate moderately higher effectiveness.
Area of Science:
- Immunology
- Epidemiology
- Vaccinology
Background:
- This paper reviews mumps vaccine safety and effectiveness, focusing on meningitis adverse events.
- Data from the National Institute of Hygiene in Warsaw and literature review inform the analysis.
Discussion:
- Vaccines with Jeryl Lynn strains present a reduced risk of aseptic meningitis compared to those using the Urabe AM 9 strain.
- Conversely, Urabe AM 9-based vaccines exhibit moderately superior effectiveness.
Key Insights:
- Comparative analysis of mumps vaccine strains (Jeryl Lynn vs. Urabe AM 9) regarding safety and efficacy.
- Evidence suggests a trade-off between the risk of meningitis and vaccine effectiveness based on the mumps virus strain used.
Outlook:
- Informing decisions on mumps vaccine selection in Poland based on safety and effectiveness profiles.
- Further research may explore newer mumps vaccine strains and their long-term outcomes.