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[Cerebral low T3 syndrome].

N D Tenedieva, V D Tenedieva, Sh Sh Eliava

    Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko
    |March 1, 2003
    PubMed
    Summary

    Subarachnoid hemorrhage disrupts thyroid hormone levels, causing a "cerebral low T3 syndrome." This condition correlates with neurological severity, vasospasm, and poor outcomes in patients.

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    Area of Science:

    • Neuroendocrinology
    • Critical Care Medicine

    Context:

    • Subarachnoid hemorrhage (SAH) is a critical neurological emergency.
    • Thyroid hormones play a vital role in brain function and metabolism.
    • Patients with SAH often experience complex physiological disturbances.

    Purpose:

    • To investigate the changes in the cerebral thyronergic system and proinflammatory cytokines in patients with acute SAH.
    • To correlate these changes with clinical condition, neurological severity, vasospasm, and patient outcomes.

    Summary:

    • This study analyzed thyroid hormones (T3, T4, TBG, TSH) and TNF-alpha in blood and CSF of 59 SAH patients.
    • A significant depression of thyroid metabolism, termed
    • cerebral low T3 syndrome
    • was observed, particularly in patients with neurological deterioration.

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  • Decreased T3 and TSH levels correlated with neurological severity, vasospasm, and adverse outcomes.
  • Elevated TNF-alpha showed negative correlations with thyroid hormone levels and neurological symptoms.

    • Impact:

    • Identifies a specific neuroendocrine disorder,
    • cerebral low T3 syndrome
    • , associated with SAH.
    • Highlights the link between thyroid dysfunction, inflammation, and neurological damage in SAH.
    • Provides potential biomarkers for predicting SAH patient outcomes and guiding therapeutic strategies.