Paget's disease of the breast. Simple method of cytological diagnosis

A simple abrasive technique for obtaining cytological material for evaluation of lesions of the mammary nipple yields samples which permit a diagnosis of Paget's disease without surgical biopsy. The lesion is abraded with the rough surface of a glass microscope slide having one frosted face; the sample is fixed with polyethylene glycol, and stained with the Papanicolaou technique. The slide is rendered transparent by the cover-slip mounting material and is evaluated according to usual cytological standards.