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[Tryptase and fatal anaphylaxic reaction]
Yi-wen Shen1, Chao Lu, Zi-qin Zhao
1Department of Forensic Medicine, Shanghai Medical School, Fudan University, Shanghai 200032. shenyiwen88@citiz.net
Fa Yi Xue Za Zhi
|March 1, 2003
Summary
Serum tryptase levels can indicate anaphylaxis, a severe allergic reaction. However, this test alone is insufficient for diagnosis, as seen in one case with normal tryptase levels.
Area of Science:
- Allergy and Immunology
- Toxicology
Context:
- Anaphylaxis is a life-threatening systemic hypersensitivity reaction.
- Serum tryptase is an enzyme released by mast cells during anaphylaxis.
Purpose:
- To investigate the relationship between serum tryptase levels and fatal anaphylaxis.
- To evaluate the utility of tryptase measurement as a diagnostic marker for anaphylaxis.
Summary:
- Serum tryptase concentrations were measured in three individuals who died from anaphylaxis using ELISA.
- Tryptase levels varied significantly, with two cases showing elevated concentrations (52 ng/ml and 121 ng/ml) and one case showing a normal level (0.73 ng/ml).
- The reason for the normal tryptase level in one fatal anaphylaxis case remains unexplained.
Impact:
- Serum tryptase measurement is a potentially useful indicator for diagnosing anaphylaxis, particularly in post-mortem investigations.
- The findings suggest that tryptase levels should be interpreted cautiously and not solely relied upon for anaphylaxis diagnosis due to potential variability.