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[Apoptosis in mouse after tetramine poisoning]
Yi-bin Cheng1, Ning-guo Liu, Jian-hua Zhang
1Institute of Forensic Sciences, Ministry of Justice, P.R. China, Shanghai 200063.
Fa Yi Xue Za Zhi
|March 1, 2003
Summary
Tetramine poisoning causes significant apoptosis in mouse organs, even in chronic cases undetectable by standard tests. Apoptosis detection offers a forensic reference for chronic tetramine exposure.
Area of Science:
- Forensic toxicology
- Cellular pathology
- Toxicology
Background:
- Tetramine poisoning is a significant toxicological concern.
- Understanding pathological changes and apoptosis is crucial for forensic identification.
- Distinguishing acute from chronic poisoning requires sensitive detection methods.
Purpose of the Study:
- To investigate pathological alterations and apoptosis in mouse organs following tetramine poisoning.
- To establish forensic references for tetramine poisoning identification.
- To compare apoptosis levels in acute versus chronic poisoning models.
Main Methods:
- An experimental mouse model of tetramine poisoning was established.
- Apoptosis detection technology was employed to quantify cellular changes.
- Computer image analysis was used to analyze staining results.
Main Results:
- Apoptosis was significantly higher in chronic poisoning groups compared to acute groups across brain, heart, liver, and kidney.
- Apoptosis levels varied based on poisoning duration and organ type.
- Standard poison analysis detected tetramine in acute cases but not in chronic cases.
Conclusions:
- Chronic tetramine poisoning, though undetectable by clinical or standard poison analysis, induces detectable apoptosis.
- Apoptosis serves as a key indicator for identifying chronic, low-dose tetramine exposure.
- These findings highlight the impact of chronic low-level poisoning on the body.
