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Retinopathy in sickle cell trait: does it exist?

Jon Nia1, Wai-Ching Lam, David M Kleinman

  • 1University of Toronto, Toronto, Ont.

Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie
|March 1, 2003
PubMed
Summary
This summary is machine-generated.

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This study found no increased risk of sickle cell retinopathy in healthy individuals with sickle cell trait. Comprehensive eye exams did not reveal any retinopathy in participants with sickle cell trait.

Area of Science:

  • Ophthalmology
  • Hematology
  • Genetics

Background:

  • Sickle cell trait (hemoglobin AS) is associated with retinopathy risk, particularly with systemic disease.
  • Retinopathy has been reported in sickle cell trait patients without systemic disease.
  • Population-based data on retinopathy risk in healthy sickle cell trait individuals is lacking.

Purpose of the Study:

  • To investigate the relationship between sickle cell trait and retinopathy in healthy subjects.
  • To determine if sickle cell trait alone increases retinopathy risk.

Main Methods:

  • Reviewed medical records of 100 children with sickle cell disease.
  • Recruited 32 participants with confirmed hemoglobin AS status for ophthalmologic examination.
  • Defined sickle cell retinopathy by specific clinical signs and performed comprehensive eye exams and blood tests.

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Main Results:

  • No cases of sickle cell retinopathy were observed in the 32 participants with sickle cell trait.
  • Elevated reticulocyte counts were noted in 10 subjects, but without associated ocular findings.

Conclusions:

  • Healthy individuals with sickle cell trait do not appear to have an increased risk of retinopathy.
  • Further research may be warranted to fully understand the ocular implications of sickle cell trait.