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Target discovery and validation in the post-genomic era.

Steven P Butcher1

  • 1Synaptica Research Ltd., 551 Harwell, Harwell International Business Centre, Didcot OX11 0QJ, United Kingdom. steve.butcher@synaptica-research.com

Neurochemical Research
|March 1, 2003
PubMed
Summary

The human genome sequence aids in combating intractable diseases and improving therapies. Genomic data can pinpoint disease origins and reduce drug development failures by identifying accurate biological targets.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Drug Discovery

Background:

  • The human genome sequence offers new avenues for treating intractable diseases and enhancing current therapies.
  • Bioinformatic and functional genomic approaches can identify the molecular basis of diseases and potential intervention points.

Purpose of the Study:

  • To explore how genomic information can improve drug discovery.
  • To reduce the high failure rate in experimental drug development by identifying appropriate biological targets.

Main Methods:

  • Reviewing approaches for identifying biologically relevant drug targets.
  • Utilizing bioinformatic and functional genomic data.

Main Results:

  • Genomic information can significantly reduce the biological failure rate in drug discovery.

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  • Early definition of drug targets related to disease susceptibility or progression is crucial.

    • Conclusions:

    • The human genome sequence is a powerful tool for advancing therapeutic development.
    • Accurate identification of drug targets is key to successful drug discovery and treatment of human diseases.