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Bistratamides E-J, modified cyclic hexapeptides from the Philippines ascidian Lissoclinum bistratum
Lark J Perez1, D John Faulkner
1Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0212.
Journal of Natural Products
|March 1, 2003
Abstract:
The Philippines ascidian Lissoclinum bistratum contained the known metabolites bistratamides C and D, together with six novel modified cyclic hexapeptides, bistratamides E-J. The structures of bistratamides E-J were elucidated by interpretation of spectral data, and the absolute stereochemistry of the constituent amino acids was determined after ozonolysis and acid-catalyzed hydrolysis. Bistratamides E-J were moderately cytotoxic in the HCT-116 cell line assay.